Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate an…

Details

scope: mouse, Lhx6 knockout, MGE transplantation
claim_text: Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position; Lhx6-/- MGE cells acquire CGE-like fate
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
effect_size: CGE-like fate in Lhx6-/- MGE cells
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: some Lhx6 −/− MGE cells acquire a CGE-like fate
study_system: mouse, Lhx6 knockout, MGE transplantation
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: In Lhx6 knockout, MGE cells adopt CGE-like identity; Arx and CXCR7 rescue divergent aspects of cell-fate and laminar phenotypes
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.neuron.2014.02.030",
  "claim": "Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position; Lhx6-/- MGE cells acquire CGE-like fate",
  "evidence": "In Lhx6 knockout, MGE cells adopt CGE-like identity; Arx and CXCR7 rescue divergent aspects of cell-fate and laminar phenotypes",
  "effect_size": "CGE-like fate in Lhx6-/- MGE cells",
  "text_access": "fulltext",
  "study_system": "mouse, Lhx6 knockout, MGE transplantation",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "some Lhx6 −/− MGE cells acquire a CGE-like fate",
  "replication_evidence_dois": [
    "10.1038/s41598-022-09003-4"
  ],
  "effect_size_source_sentence": "some Lhx6 −/− MGE cells acquire a CGE-like fate"
}

source_refs

[
  "paper:paper-09e3387a22aa"
]

evidence_refs

[
  {
    "ref": "paper:paper-09e3387a22aa"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate an…

Details

Replication

Discussion