MEIS2 and DLX5 cooperate at enhancer elements to promote projection neuron fate…

Details

scope: mouse, in vivo CRISPR perturbation + lineage tracing
claim_text: MEIS2 and DLX5 cooperate at enhancer elements to promote projection neuron fate while LHX6 represses this in interneuron precursors
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: In interneuron precursors, the transcription factor LHX6 represses the MEIS2–DLX5-dependent activation of projection-neuron-specific enhancers.
study_system: mouse, in vivo CRISPR perturbation + lineage tracing
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: Differential binding model: transcription factor binding at cis-regulatory elements determines cell fate specification in ganglionic eminence
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/s41593-024-01611-9",
  "claim": "MEIS2 and DLX5 cooperate at enhancer elements to promote projection neuron fate while LHX6 represses this in interneuron precursors",
  "evidence": "Differential binding model: transcription factor binding at cis-regulatory elements determines cell fate specification in ganglionic eminence",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse, in vivo CRISPR perturbation + lineage tracing",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In interneuron precursors, the transcription factor LHX6 represses the MEIS2–DLX5-dependent activation of projection-neuron-specific enhancers.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-96ec1199d9ce"
]

evidence_refs

[
  {
    "ref": "paper:paper-96ec1199d9ce"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

MEIS2 and DLX5 cooperate at enhancer elements to promote projection neuron fate…

Details

Replication

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