Details
- scope
- mouse, Dot1l conditional knockout in Nkx2.1 lineage
- claim_text
- DOT1L histone methyltransferase is required for PV interneuron development; its deletion in Nkx2.1-expressing precursors causes significant PV+ interneuron reduction
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- significant decrease in PV+ interneurons, decreased mitotic cells at E14.5
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Deletion of Dot1l in Nkx2.1-expressing interneuron precursor cells results in an overall reduction and altered distribution of GABAergic interneurons in the CP from postnatal day 0 onwards.
- study_system
- mouse, Dot1l conditional knockout in Nkx2.1 lineage
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- Cell-autonomous effect: significant decrease in PV-expressing interneurons with premature cell cycle exit at E14.5
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 3, "doi": "10.1093/cercor/bhad281", "claim": "DOT1L histone methyltransferase is required for PV interneuron development; its deletion in Nkx2.1-expressing precursors causes significant PV+ interneuron reduction", "evidence": "Cell-autonomous effect: significant decrease in PV-expressing interneurons with premature cell cycle exit at E14.5", "effect_size": "significant decrease in PV+ interneurons, decreased mitotic cells at E14.5", "text_access": "fulltext", "study_system": "mouse, Dot1l conditional knockout in Nkx2.1 lineage", "replication_status": "replication_unknown", "claim_source_sentence": "Deletion of Dot1l in Nkx2.1-expressing interneuron precursor cells results in an overall reduction and altered distribution of GABAergic interneurons in the CP from postnatal day 0 onwards.", "replication_evidence_dois": [], "effect_size_source_sentence": "we observed an altered proportion of GABAergic interneurons in the cortex, with a significant decrease in parvalbumin-expressing interneurons" }- source_refs
[ "paper:paper-616950b87f7f" ]
- evidence_refs
[ { "ref": "paper:paper-616950b87f7f" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }