Details
- scope
- mouse, Satb1 conditional knockout
- claim_text
- SATB1 is required for the maturation of MGE-derived cortical interneurons including parvalbumin expression
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- dramatic decrease in PV+ cells, SST+ largely unaffected
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Satb1 mutant cortex showed a dramatic decrease in the number of cells expressing PV, while the number of SST-expressing cells was largely unaffected.
- study_system
- mouse, Satb1 conditional knockout
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- Loss of Satb1 leads to dramatic loss of PV interneurons with preserved SST numbers, indicating SATB1 acts downstream of Lhx6 in PV specification
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 3, "doi": "10.1016/j.celrep.2012.10.003", "claim": "SATB1 is required for the maturation of MGE-derived cortical interneurons including parvalbumin expression", "evidence": "Loss of Satb1 leads to dramatic loss of PV interneurons with preserved SST numbers, indicating SATB1 acts downstream of Lhx6 in PV specification", "effect_size": "dramatic decrease in PV+ cells, SST+ largely unaffected", "text_access": "fulltext", "study_system": "mouse, Satb1 conditional knockout", "replication_status": "independently_replicated", "claim_source_sentence": "Satb1 mutant cortex showed a dramatic decrease in the number of cells expressing PV, while the number of SST-expressing cells was largely unaffected.", "replication_evidence_dois": [ "10.1016/j.neuron.2014.02.030" ], "effect_size_source_sentence": "Satb1 mutant cortex showed a dramatic decrease in the number of cells expressing PV, while the number of SST-expressing cells was largely unaffected." }- source_refs
[ "paper:paper-a41ff0022587" ]
- evidence_refs
[ { "ref": "paper:paper-a41ff0022587" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }