D-serine availability via serine racemase is essential for prenatal cortical in…

Details

scope: mouse, serine racemase knockout (SR-/-)
claim_text: D-serine availability via serine racemase is essential for prenatal cortical interneuron development, with SR knockout causing significant PV+ but not SST+ CIN reduction
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
effect_size: significant decrease in GAD67+ and PV+ density at PND16
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: In the PrL of postnatal day (PND) 16 SR −/− mice, there was a significant decrease in GAD67+ and PV+, but not SST + CIN density
study_system: mouse, serine racemase knockout (SR-/-)
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: Serine racemase knockout mice showed accumulated GABA and increased mitotic proliferation in ganglionic eminence at E15, fewer Gad1+ cells in E18 neocortex
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1038/s41598-023-35615-5",
  "claim": "D-serine availability via serine racemase is essential for prenatal cortical interneuron development, with SR knockout causing significant PV+ but not SST+ CIN reduction",
  "evidence": "Serine racemase knockout mice showed accumulated GABA and increased mitotic proliferation in ganglionic eminence at E15, fewer Gad1+ cells in E18 neocortex",
  "effect_size": "significant decrease in GAD67+ and PV+ density at PND16",
  "text_access": "fulltext",
  "study_system": "mouse, serine racemase knockout (SR-/-)",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "In the PrL of postnatal day (PND) 16 SR −/− mice, there was a significant decrease in GAD67+ and PV+, but not SST + CIN density",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "In the PrL of postnatal day (PND) 16 SR −/− mice, there was a significant decrease in GAD67+ and PV+, but not SST + CIN density, which was associated with reduced inhibitory postsynaptic potentials in layer 2/3 pyramidal neurons."
}

source_refs

[
  "paper:paper-539c07f839a7"
]

evidence_refs

[
  {
    "ref": "paper:paper-539c07f839a7"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

D-serine availability via serine racemase is essential for prenatal cortical in…

Details

Replication

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