Details

scope
entorhinal cortex interneurons, in vitro dynamic clamp + computational model
claim_text
PV+ fast-firing basket cells are more likely to exhibit class 2 excitability with post-inhibitory rebound than other interneuron types, enabling more robust ING gamma synchronization in the presence of noise and heterogeneity
section_id
section_07_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json
effect_size
Robustness to heterogeneity increases as average participation approximates physiological levels (~every other cycle)
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-07
source_kind
review_finding
source_path
evidence/section_07_evidence_package.json
study_system
entorhinal cortex interneurons, in vitro dynamic clamp + computational model
section_title
Local Circuit Motifs: Perisomatic Inhibition, Feedback, and Feedforward
evidence_summary
Computational modeling and dynamic clamp experiments in entorhinal cortical interneurons
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
single study
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-07
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_07_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (5)
raw_fields
{
  "n": 0,
  "doi": "10.1523/jneurosci.2601-15.2015",
  "claim": "PV+ fast-firing basket cells are more likely to exhibit class 2 excitability with post-inhibitory rebound than other interneuron types, enabling more robust ING gamma synchronization in the presence of noise and heterogeneity",
  "evidence": "Computational modeling and dynamic clamp experiments in entorhinal cortical interneurons",
  "effect_size": "Robustness to heterogeneity increases as average participation approximates physiological levels (~every other cycle)",
  "text_access": "abstract_only",
  "study_system": "entorhinal cortex interneurons, in vitro dynamic clamp + computational model",
  "replication_status": "single study",
  "claim_source_sentence": "PV+ cells were much more likely to display both PIR and autapse-induced firing than GAD2+ cells, supporting the view that PV+ fast-firing basket cells are more likely to exhibit class 2 excitability than other types of inhibitory interneurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "This results in much greater robustness to heterogeneity that actually increases as the average participation in spikes per cycle approximates physiological levels."
}
source_refs
[
  "paper:paper-cde5b8227f4d"
]
source_span
PV+ cells were much more likely to display both PIR and autapse-induced firing than GAD2+ cells, supporting the view that PV+ fast-firing basket cells are more likely to exhibit class 2 excitability than other types of inhibitory interneurons.
evidence_refs
[
  {
    "ref": "paper:paper-cde5b8227f4d"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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