- claim_text
Layer 4 SOM interneurons primarily target fast-spiking interneurons rather than pyramidal cells, creating a disinhibitory microcircuit in the thalamorecipient layer where SOM inhibition of FS cells paradoxically decreases firing of principal neurons
- raw_fields
{
"n": 0,
"doi": "10.1016/j.neuron.2012.11.004",
"claim": "Layer 4 SOM interneurons primarily target fast-spiking interneurons rather than pyramidal cells, creating a disinhibitory microcircuit in the thalamorecipient layer where SOM inhibition of FS cells paradoxically decreases firing of principal neurons",
"evidence": "Optogenetic inhibition of SOM INs with parallel electrophysiological recordings in active cortical networks",
"effect_size": "Optogenetic SOM inhibition increased L2/3 PC firing but decreased L4 PN firing",
"text_access": "fulltext",
"study_system": "mouse somatosensory cortex, in vitro",
"replication_status": "within-lab",
"claim_source_sentence": "Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas decreases the firing of layer 4 principal neurons (PNs).",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas decreases the firing of layer 4 principal neurons (PNs)."
}- source_refs
[
"paper:paper-92bf23cf430e"
]
- source_span
Moreover, we found that whereas layers 2/3 SOM INs target mainly pyramidal cells (PCs), layer 4 SOM INs target mainly fast-spiking (FS) INs. Accordingly, optogenetic inhibition of SOM INs in an active cortical network increases the firing of layers 2/3 PCs whereas decreases the firing of layer 4 principal neurons (PNs).
- evidence_refs
[
{
"ref": "paper:paper-92bf23cf430e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}