Hippocampal long-range nNOS+ inhibitory cells (LINCs), distinct from VIP and SS…

Hippocampal long-range nNOS+ inhibitory cells (LINCs), distinct from VIP and SST cells, project to extrahippocampal regions and modulate CA1 oscillations and interregional coherence, illustrating that VIP-negative inhibitory long-range projection cells also shape hippocampal rhythms.

{
  "n": null,
  "doi": "10.7554/elife.46816",
  "pmid": "31609204",
  "year": "2019",
  "claim": "Hippocampal long-range nNOS+ inhibitory cells (LINCs), distinct from VIP and SST cells, project to extrahippocampal regions and modulate CA1 oscillations and interregional coherence, illustrating that VIP-negative inhibitory long-range projection cells also shape hippocampal rhythms.",
  "pmcid": "PMC6839902",
  "title": "Novel long-range inhibitory nNOS-expressing hippocampal cells.",
  "authors": "",
  "journal": "",
  "cite_key": "Christensonwick2019",
  "evidence": "Intersectional viral genetics, anatomical tracing, slice electrophysiology, and chemogenetic manipulation in mice; in vivo LFP coherence.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "LINC manipulation alters hippocampal oscillations and interregional coherence",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "mouse hippocampal CA1 + extrahippocampal targets; in vivo LFP",
  "cited_by_count": 32,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 20,
  "claim_source_sentence": "LINCs are thus both interneurons and projection neurons. LINCs display regular spiking non-pyramidal firing patterns, are primarily located in the stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2. We further demonstrate that LINCs can strongly influence hippocampal function and oscillations, including interregional coherence.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "LINCs can strongly influence hippocampal function and oscillations, including interregional coherence."
}

[
  "paper:paper-83601c612acb"
]

LINCs are thus both interneurons and projection neurons. LINCs display regular spiking non-pyramidal firing patterns, are primarily located in the stratum oriens or pyramidale, have sparsely spiny dendrites, and do not typically express somatostatin, VIP, or the muscarinic acetylcholine receptor M2. We further demonstrate that LINCs can strongly influence hippocampal function and oscillations, including interregiona...

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  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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