Comprehensive single-cell RNA sequencing of ~1.3 million cells across adult mou…

Comprehensive single-cell RNA sequencing of ~1.3 million cells across adult mouse isocortex and hippocampal formation produced a transcriptomic taxonomy revealing a full repertoire of glutamatergic and GABAergic types, including a complete set of glutamatergic types in HPF homologous to all major isocortical subclasses.

{
  "n": 1300000,
  "doi": "10.1016/j.cell.2021.04.021",
  "claim": "Comprehensive single-cell RNA sequencing of ~1.3 million cells across adult mouse isocortex and hippocampal formation produced a transcriptomic taxonomy revealing a full repertoire of glutamatergic and GABAergic types, including a complete set of glutamatergic types in HPF homologous to all major isocortical subclasses.",
  "cite_key": "Yao2021a",
  "evidence": "Whole-isocortex+HPF scRNA-seq with cluster-based taxonomy construction in adult mouse.",
  "effect_size": "~1.3 million cells profiled across adult mouse isocortex and HPF",
  "text_access": "abstract_only",
  "study_system": "adult mouse isocortex and hippocampal formation",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We profiled ~1.3 million cells covering the entire adult mouse isocortex and HPF and derived a transcriptomic cell-type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-018-0654-5",
    "10.1038/s41586-021-03950-0",
    "10.1038/s41586-023-06812-z"
  ],
  "effect_size_source_sentence": "We profiled ~1.3 million cells covering the entire adult mouse isocortex and HPF and derived a transcriptomic cell-type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types."
}

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    "Local review repositories are read-only inputs.",
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