- claim_text
Pedunculopontine nucleus glutamatergic neurons project to the striatum and selectively excite striatal cholinergic and fast-spiking GABAergic interneurons rather than spiny projection neurons, generating disynaptic feedforward inhibition of SPNs.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.2913-18.2019",
"claim": "Pedunculopontine nucleus glutamatergic neurons project to the striatum and selectively excite striatal cholinergic and fast-spiking GABAergic interneurons rather than spiny projection neurons, generating disynaptic feedforward inhibition of SPNs.",
"cite_key": "Assous2019b",
"evidence": "VGLUT2-Cre + ChR2 with patch-clamp ex vivo and in vivo single-unit recording during opto stim; behavioral head rotation assay.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "VGLUT2-Cre mouse, dorsal striatum",
"source_cluster_id": "cluster_10",
"replication_status": "replication_unknown",
"claim_source_sentence": "Specifically, optogenetic activation of glutamatergic axons from the pedunculopontine nucleus induced monosynaptic excitation in most recorded striatal cholinergic interneurons and GABAergic fast-spiking interneurons.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-93927a11e711"
]
- evidence_refs
[
{
"ref": "paper:paper-93927a11e711"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}