Details

scope
adult male mouse cortico-STN-SNr
claim_text
Selective photochemical elimination of cortico-STN projections in mice abolishes cortically-evoked early excitation in SNr and produces motor hyperactivity, consistent with the hyperdirect pathway suppressing ongoing cortical activity.
section_id
section_11
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
review_repo
ComputationalReviewLoops
section_ref
wiki_page:computationalreviewloops-11
source_kind
review_finding
source_path
evidence/section_11_evidence_package.json
study_system
adult male mouse cortico-STN-SNr
section_title
Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
evidence_summary
Photodynamic lesioning of cortico-STN axons + SNr in vivo single-unit recordings + locomotor assays.
review_bundle_ref
analysis_bundle:ab-d49e54403ef9
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-d49e54403ef9
source_artifact_ref
wiki_page:computationalreviewloops-11
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
commit_sha
0632aae8abc141909207fe91f6349b9e36489c3b
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (5)
raw_fields
{
  "n": 0,
  "doi": "10.1523/jneurosci.1330-20.2021",
  "claim": "Selective photochemical elimination of cortico-STN projections in mice abolishes cortically-evoked early excitation in SNr and produces motor hyperactivity, consistent with the hyperdirect pathway suppressing ongoing cortical activity.",
  "cite_key": "Koketsu2021",
  "evidence": "Photodynamic lesioning of cortico-STN axons + SNr in vivo single-unit recordings + locomotor assays.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "adult male mouse cortico-STN-SNr",
  "source_cluster_id": "cluster_10",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "After cortico-STN elimination, cortically evoked early excitation in the SNr was diminished, while the cortically evoked inhibition and late excitation, which are delivered through the direct and indirect pathways, respectively, were unchanged.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-68824b03d404"
]
source_span
After cortico-STN elimination, cortically evoked early excitation in the SNr was diminished, while the cortically evoked inhibition and late excitation, which are delivered through the direct and indirect pathways, respectively, were unchanged.
evidence_refs
[
  {
    "ref": "paper:paper-68824b03d404"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

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