Details
- scope
- mouse striatal slice, ChAT-Cre and D2-Cre lines
- claim_text
- Optogenetic activation of striatal cholinergic interneurons elicits feedforward inhibition of D2-MSNs and modulates indirect-pathway output.
- section_id
- section_11
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- effect_size
- 50%
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- Tardive dyskinesia (TD) is a drug-induced movement disorder that arises with antipsychotics.
- study_system
- mouse striatal slice, ChAT-Cre and D2-Cre lines
- section_title
- Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
- evidence_summary
- ChR2 stimulation of ChAT-Cre cholinergic interneurons with patch-clamp recordings from D2-Cre identified medium spiny neurons.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.expneurol.2016.09.009", "claim": "Optogenetic activation of striatal cholinergic interneurons elicits feedforward inhibition of D2-MSNs and modulates indirect-pathway output.", "cite_key": "Bordia2016", "evidence": "ChR2 stimulation of ChAT-Cre cholinergic interneurons with patch-clamp recordings from D2-Cre identified medium spiny neurons.", "effect_size": "50%", "text_access": "abstract_only", "study_system": "mouse striatal slice, ChAT-Cre and D2-Cre lines", "source_cluster_id": "cluster_10", "replication_status": "replication_unknown", "claim_source_sentence": "Tardive dyskinesia (TD) is a drug-induced movement disorder that arises with antipsychotics.", "replication_evidence_dois": [], "effect_size_source_sentence": "Optical stimulation of striatal cholinergic interneurons using cholineacetyltransferase (ChAT)-Cre mice expressing channelrhodopsin2-eYFP decreased haloperidol-induced VCMs (~50%), with no effect in control-eYFP mice." }- source_refs
[ "paper:paper-63aca9cf07b0" ]
- evidence_refs
[ { "ref": "paper:paper-63aca9cf07b0" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }