Optogenetic activation of dorsal striatal D1R neurons drives immediate NREM-to-…

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scope: mouse, dorsal striatum D1R-Cre
claim_text: Optogenetic activation of dorsal striatal D1R neurons drives immediate NREM-to-wake transitions while chemogenetic inhibition attenuates wakefulness in mice.
section_id: section_11
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-11
source_kind: review_finding
source_path: evidence/section_11_evidence_package.json
source_span: As a result, optogenetic activation of striatal D1R neurons induced immediate transitions from non-rapid eye movement (NREM) sleep to wakefulness, whereas inhibition of striatal D1R neurons attenuated wakefulness by chemogenetics.
study_system: mouse, dorsal striatum D1R-Cre
section_title: Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
evidence_summary: ChR2/Arch optogenetics + DREADD inhibition + fiber photometry + EEG/EMG in D1R-Cre mice.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-11
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.cub.2021.12.026",
  "claim": "Optogenetic activation of dorsal striatal D1R neurons drives immediate NREM-to-wake transitions while chemogenetic inhibition attenuates wakefulness in mice.",
  "cite_key": "Dong2022",
  "evidence": "ChR2/Arch optogenetics + DREADD inhibition + fiber photometry + EEG/EMG in D1R-Cre mice.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse, dorsal striatum D1R-Cre",
  "source_cluster_id": "cluster_10",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "As a result, optogenetic activation of striatal D1R neurons induced immediate transitions from non-rapid eye movement (NREM) sleep to wakefulness, whereas inhibition of striatal D1R neurons attenuated wakefulness by chemogenetics.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-7374718361ea"
]

evidence_refs

[
  {
    "ref": "paper:paper-7374718361ea"
  }
]

source_policy

{
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  "notes": [
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Optogenetic activation of dorsal striatal D1R neurons drives immediate NREM-to-…

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