- claim_text
Optogenetic and pharmacological dissection in mouse slices demonstrates histamine differentially modulates corticostriatal vs thalamostriatal synapses and lateral inhibition between MSNs (suppressed) but spares feedforward inhibition from fast-spiking GABAergic interneurons.
- raw_fields
{
"n": 0,
"doi": "10.1523/jneurosci.3144-11.2011",
"claim": "Optogenetic and pharmacological dissection in mouse slices demonstrates histamine differentially modulates corticostriatal vs thalamostriatal synapses and lateral inhibition between MSNs (suppressed) but spares feedforward inhibition from fast-spiking GABAergic interneurons.",
"cite_key": "Ellender2011",
"evidence": "Patch-clamp + electrical/optogenetic stimulation of cortical and thalamic afferents.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse striatum slice",
"source_cluster_id": "cluster_10",
"replication_status": "replication_unknown",
"claim_source_sentence": "Subsequent dual whole-cell patch-clamp recordings of connected pairs of striatal neurons revealed that only lateral inhibition between MSNs is negatively modulated, whereas feedforward inhibition from fast-spiking GABAergic interneurons onto MSNs is unaffected by histamine.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-4008318251a6"
]
- source_span
Subsequent dual whole-cell patch-clamp recordings of connected pairs of striatal neurons revealed that only lateral inhibition between MSNs is negatively modulated, whereas feedforward inhibition from fast-spiking GABAergic interneurons onto MSNs is unaffected by histamine.
- evidence_refs
[
{
"ref": "paper:paper-4008318251a6"
}
]- source_policy
{
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}