- claim_text
Mono-synaptic retrograde tracers RV-ΔG and rAAV2-retro show distinct neurotropism: rAAV2-retro preferentially labels cerebral cortex while RV-ΔG preferentially labels basal ganglia and hypothalamus, with cortical layer biases (layer 5 vs layer 6) when injected into LGN.
- raw_fields
{
"n": 3,
"doi": "10.1186/s13024-019-0308-6",
"claim": "Mono-synaptic retrograde tracers RV-ΔG and rAAV2-retro show distinct neurotropism: rAAV2-retro preferentially labels cerebral cortex while RV-ΔG preferentially labels basal ganglia and hypothalamus, with cortical layer biases (layer 5 vs layer 6) when injected into LGN.",
"cite_key": "Sun2019",
"evidence": "Side-by-side comparison; RNA-seq of infected neurons; immunohistochemistry of microglial activation.",
"effect_size": "5 and",
"text_access": "fulltext",
"study_system": "mouse circuits (popliteal lymph nodes, LH, MPO, dLGN)",
"source_cluster_id": "cluster_10",
"replication_status": "replication_unknown",
"claim_source_sentence": "Mono-synaptic retrograde tracers, including RV-∆G and rAAV2-retro, displayed discrepant neurotropic property, when they were applied to trace the inputs of lateral hypothalamic area and medial preoptic nucleus. rAAV2-retro demonstrated preference in cerebral cortex, whereas RV-∆G prefers to label basal ganglia and hypothalamus.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Remarkably, we detected a distinct preference for specific cortical layer of rAAV2-retro in layer 5 and RV-∆G in layer 6 when they were injected into dorsal lateral geniculate nucleus to label corticothalamic neurons in primary visual cortex."
}- source_refs
[
"paper:paper-47a79a5a18f5"
]
- source_span
Mono-synaptic retrograde tracers, including RV-∆G and rAAV2-retro, displayed discrepant neurotropic property, when they were applied to trace the inputs of lateral hypothalamic area and medial preoptic nucleus. rAAV2-retro demonstrated preference in cerebral cortex, whereas RV-∆G prefers to label basal ganglia and hypothalamus.
- evidence_refs
[
{
"ref": "paper:paper-47a79a5a18f5"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}