Acute itch decreases intrinsic excitability selectively in NAc Drd1-MSNs (not D…

Details

scope: adult male mouse, NAc core, D1-Cre and D2-Cre
claim_text: Acute itch decreases intrinsic excitability selectively in NAc Drd1-MSNs (not Drd2-MSNs) and chemogenetic activation of NAc Drd1-MSNs alleviates scratching behavior.
section_id: section_11
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
effect_size: 48
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-11
source_kind: review_finding
source_path: evidence/section_11_evidence_package.json
source_span: We found that acute itch induced by compound 48/80 (C48/80) decreased the intrinsic membrane excitability in Drd1-MSNs, but not in Drd2-MSNs, in the NAc core of male mice.
study_system: adult male mouse, NAc core, D1-Cre and D2-Cre
section_title: Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
evidence_summary: Patch clamp + chemogenetic activation of D1-Cre defined NAc neurons; mPFC-NAc circuit isolation.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-11
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1523/jneurosci.1359-22.2023",
  "claim": "Acute itch decreases intrinsic excitability selectively in NAc Drd1-MSNs (not Drd2-MSNs) and chemogenetic activation of NAc Drd1-MSNs alleviates scratching behavior.",
  "cite_key": "Wu2023a",
  "evidence": "Patch clamp + chemogenetic activation of D1-Cre defined NAc neurons; mPFC-NAc circuit isolation.",
  "effect_size": "48",
  "text_access": "abstract_only",
  "study_system": "adult male mouse, NAc core, D1-Cre and D2-Cre",
  "source_cluster_id": "cluster_10",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "We found that acute itch induced by compound 48/80 (C48/80) decreased the intrinsic membrane excitability in Drd1-MSNs, but not in Drd2-MSNs, in the NAc core of male mice.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "We found that acute itch induced by compound 48/80 (C48/80) decreased the intrinsic membrane excitability in Drd1-MSNs, but not in Drd2-MSNs, in the NAc core of male mice."
}

source_refs

[
  "paper:paper-571dcf2841dc"
]

evidence_refs

[
  {
    "ref": "paper:paper-571dcf2841dc"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

Acute itch decreases intrinsic excitability selectively in NAc Drd1-MSNs (not D…

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Replication

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