Details
- scope
- mouse striatum slice, ChAT-Cre
- claim_text
- Optogenetic activation of striatal cholinergic interneurons disynaptically inhibits spiny projection neurons via recruitment of nicotinic-receptor-expressing GABAergic interneurons rather than direct muscarinic effects.
- section_id
- section_11
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-11
- source_kind
- review_finding
- source_path
- evidence/section_11_evidence_package.json
- source_span
- UnlabelledSynchronous optogenetic activation of striatal cholinergic interneurons ex vivo produces a disynaptic inhibition of spiny projection neurons composed of biophysically distinct GABAAfast and GABAAslow components.
- study_system
- mouse striatum slice, ChAT-Cre
- section_title
- Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing)
- evidence_summary
- ChAT-ChR2 in slice with pharmacological dissection (mecamylamine, atropine) and patch-clamp from SPNs.
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-11
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_11_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.0466-16.2016", "claim": "Optogenetic activation of striatal cholinergic interneurons disynaptically inhibits spiny projection neurons via recruitment of nicotinic-receptor-expressing GABAergic interneurons rather than direct muscarinic effects.", "cite_key": "Faust2016", "evidence": "ChAT-ChR2 in slice with pharmacological dissection (mecamylamine, atropine) and patch-clamp from SPNs.", "effect_size": null, "text_access": "abstract_only", "study_system": "mouse striatum slice, ChAT-Cre", "source_cluster_id": "cluster_10", "replication_status": "independently_replicated", "claim_source_sentence": "UnlabelledSynchronous optogenetic activation of striatal cholinergic interneurons ex vivo produces a disynaptic inhibition of spiny projection neurons composed of biophysically distinct GABAAfast and GABAAslow components.", "replication_evidence_dois": [ "10.1016/j.expneurol.2016.09.009", "10.1523/jneurosci.1627-21.2022" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-1ed88f8ddfec" ]
- evidence_refs
[ { "ref": "paper:paper-1ed88f8ddfec" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }