- claim_text
Isoform-resolved SMART-seq of 6,160 mouse M1 cells combined with MERFISH (280,327 cells) and 10x Genomics (94,162 cells) reveals isoform-shift markers between transcriptomic cell types that are masked at gene-level analysis, refining the M1 cell-type taxonomy at the isoform level.
- raw_fields
{
"n": 380649,
"doi": "10.1038/s41586-021-03969-3",
"claim": "Isoform-resolved SMART-seq of 6,160 mouse M1 cells combined with MERFISH (280,327 cells) and 10x Genomics (94,162 cells) reveals isoform-shift markers between transcriptomic cell types that are masked at gene-level analysis, refining the M1 cell-type taxonomy at the isoform level.",
"cite_key": "Booeshaghi2021",
"evidence": "SMART-seq full-length, MERFISH spatial transcriptomic and 10x Genomics short-read profiling of mouse M1 with cross-platform integration.",
"effect_size": "qualitative — isoform-level resolution refines cell-type taxonomy beyond gene-level",
"text_access": "fulltext",
"study_system": "mouse primary motor cortex (M1) cell-type taxonomy",
"argument_role": "supporting",
"replication_status": "single_study",
"claim_source_sentence": "we find examples of isoform specificity in cell types—including isoform shifts between cell types that are masked in gene-level analysis—as well as examples of transcriptional regulation",
"source_provenance_status": "ok",
"replication_evidence_dois": [],
"effect_size_source_sentence": "examples of isoform specificity in cell types—including isoform shifts between cell types that are masked in gene-level analysis"
}- source_refs
[
"paper:paper-9443e876ca93"
]
- evidence_refs
[
{
"ref": "paper:paper-9443e876ca93"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}