In mouse auditory cortex, bath nicotine strongly and directly depolarizes VIP i…

In mouse auditory cortex, bath nicotine strongly and directly depolarizes VIP interneurons, and chemogenetic VIP silencing prevents nicotine-driven disinhibition of pyramidal neurons, providing a cell-type basis for nicotine-induced enhancement of sensory cortical processing.

{
  "n": null,
  "doi": "10.1002/syn.22116",
  "year": "2019",
  "claim": "In mouse auditory cortex, bath nicotine strongly and directly depolarizes VIP interneurons, and chemogenetic VIP silencing prevents nicotine-driven disinhibition of pyramidal neurons, providing a cell-type basis for nicotine-induced enhancement of sensory cortical processing.",
  "title": "Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex",
  "journal": "",
  "species": "mouse",
  "cite_key": "Askew2019",
  "evidence": "In vitro whole-cell recordings of identified Pyr/PV/SST/VIP cells; DREADD silencing of VIP cells.",
  "effect_size": "VIP depolarized strongly by nicotine; sIPSC frequency increased in Pyr/VIP/SST but not PV cells; chemogenetic VIP silencing eliminated nicotine effects on Pyr.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "single_study",
  "_source_cluster_index": 11,
  "claim_source_sentence": "Bath application of nicotine strongly depolarized and excited VIP neurons, weakly depolarized Pyr neurons, and had no effect on the membrane potential of SOM or PV neurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Using Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), we show that chemogenetic inhibition of VIP neurons prevents nicotine's effects on Pyr neurons."
}

[
  "paper:paper-a4f1bff9ccc6"
]

[
  {
    "ref": "paper:paper-a4f1bff9ccc6"
  }
]

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  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}