In mouse prelimbic prefrontal cortex, D1 dopamine receptors are enriched in pyr…

In mouse prelimbic prefrontal cortex, D1 dopamine receptors are enriched in pyramidal cells of layers 5 and 6 that project to intratelencephalic targets (contralateral cortex, striatum, claustrum) — not to extratelencephalic targets — and in VIP+ interneurons co-expressing calretinin, but not in PV+ or SST+ interneurons; D1 activation selectively enhances firing of a subset of these IT pyramids and VIP+ interneurons, defining cell-type-specific dopaminergic modulation of PFC microcircuits.

{
  "n": 0,
  "doi": "10.1093/cercor/bhy299",
  "claim": "In mouse prelimbic prefrontal cortex, D1 dopamine receptors are enriched in pyramidal cells of layers 5 and 6 that project to intratelencephalic targets (contralateral cortex, striatum, claustrum) — not to extratelencephalic targets — and in VIP+ interneurons co-expressing calretinin, but not in PV+ or SST+ interneurons; D1 activation selectively enhances firing of a subset of these IT pyramids and VIP+ interneurons, defining cell-type-specific dopaminergic modulation of PFC microcircuits.",
  "cite_key": "Anastasiades2019",
  "evidence": "Cell-type-targeted patch-clamp recording combined with retrograde tracing and D1 agonist application in mouse prelimbic PFC slices.",
  "effect_size": "qualitative — IT-pyramid- and VIP+-interneuron-restricted D1 expression and modulation in mouse PFC",
  "text_access": "abstract_only",
  "study_system": "mouse prelimbic PFC pyramidal projection classes and interneurons",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "we examine D1 receptor expression and modulation at specific cell types and layers in the mouse prelimbic PFC. We first show that D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets including contralateral cortex, striatum, and claustrum rather than to extratelencephalic structures. We then find that D1 receptors are also present in interneurons and enriched in superficial layer VIP-positive (VIP+) interneurons that coexpresses calretinin but absent from parvalbumin-positive (PV+) and somatostatin-positive (SOM+) interneurons. Finally, we determine that D1 receptors strongly and selectively enhance action potential firing in only a subset of these corticocortical neurons and VIP+ interneurons",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets"
}

[
  "paper:paper-54d3b0c8acb7"
]

we examine D1 receptor expression and modulation at specific cell types and layers in the mouse prelimbic PFC. We first show that D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets including contralateral cortex, striatum, and claustrum rather than to extratelencephalic structures. We then find that D1 receptors are also present in interneu...

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