- claim_text
Hippocampal CA1 VIP interneurons form functional subpopulations whose activity is shaped by behavioral states and task demands, and optogenetic manipulation shows VIP disinhibition is necessary for goal-oriented spatial learning — extending neuromodulator-driven VIP recruitment beyond cortex to hippocampus.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2019.01.009",
"year": "2019",
"claim": "Hippocampal CA1 VIP interneurons form functional subpopulations whose activity is shaped by behavioral states and task demands, and optogenetic manipulation shows VIP disinhibition is necessary for goal-oriented spatial learning — extending neuromodulator-driven VIP recruitment beyond cortex to hippocampus.",
"title": "Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning",
"journal": "",
"species": "mouse",
"cite_key": "Turi2019",
"evidence": "Chronic two-photon Ca2+ imaging + optogenetics in CA1 of mice during random foraging vs. goal-oriented tasks.",
"effect_size": "VIP silencing impaired goal-directed learning and altered place-cell representations.",
"text_access": "fulltext",
"_source_cluster": "cluster_13_neuromodulation",
"replication_status": "single_study",
"_source_cluster_index": 31,
"claim_source_sentence": "VIP+ INs in hippocampal area CA1 form functional subpopulations defined by their modulation by behavioral states and task demands.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Optogenetic manipulations of VIP+ INs and computational modeling further showed that VIP+ disinhibition is necessary for goal-directed learning and related reorganization of hippocampal pyramidal cell population dynamics."
}- source_refs
[
"paper:paper-c0f52ec4cd1c"
]
- evidence_refs
[
{
"ref": "paper:paper-c0f52ec4cd1c"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}