In mouse motor cortex, cortical and thalamic excitatory inputs converge onto L5…

In mouse motor cortex, cortical and thalamic excitatory inputs converge onto L5 pyramidal neurons in layer- and cell-type-specific patterns, with L2/3 and L5A intracortical inputs and motor-thalamic inputs distributed across L5 pyramidal subtypes (corticospinal/corticostriatal/cortico-cortical) according to soma sub-layer and projection class.

{
  "n": 0,
  "doi": "10.1523/jneurosci.4338-12.2013",
  "claim": "In mouse motor cortex, cortical and thalamic excitatory inputs converge onto L5 pyramidal neurons in layer- and cell-type-specific patterns, with L2/3 and L5A intracortical inputs and motor-thalamic inputs distributed across L5 pyramidal subtypes (corticospinal/corticostriatal/cortico-cortical) according to soma sub-layer and projection class.",
  "cite_key": "Hooks2013",
  "evidence": "LSPS glutamate-uncaging mapping and channelrhodopsin-assisted circuit mapping (CRACM) of thalamocortical input combined with retrograde labeling of L5 pyramidal projection classes in mouse motor cortex slices.",
  "effect_size": "qualitative — sub-layer × projection-class specificity of intracortical and thalamocortical inputs to L5 pyramids",
  "text_access": "abstract_only",
  "study_system": "mouse primary motor cortex, L5 pyramidal projection classes",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Organization of Cortical and Thalamic Input to Pyramidal Neurons in Mouse Motor Cortex",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/nn.2538",
    "10.7554/eLife.66836"
  ],
  "effect_size_source_sentence": "Organization of Cortical and Thalamic Input to Pyramidal Neurons in Mouse Motor Cortex"
}

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