Long-range cortical inputs from primary motor cortex preferentially engage VIP…

Long-range cortical inputs from primary motor cortex preferentially engage VIP interneurons in S1, providing a route by which top-down/motor neuromodulator-state signals (carrying ACh and other neuromodulator timing) bias VIP recruitment, vs. somatosensory cortex inputs that bias PV cells.

{
  "n": null,
  "doi": "10.1016/j.celrep.2021.108774",
  "year": "2021",
  "claim": "Long-range cortical inputs from primary motor cortex preferentially engage VIP interneurons in S1, providing a route by which top-down/motor neuromodulator-state signals (carrying ACh and other neuromodulator timing) bias VIP recruitment, vs. somatosensory cortex inputs that bias PV cells.",
  "title": "Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs",
  "journal": "",
  "species": "mouse",
  "cite_key": "Naskar2021",
  "evidence": "Channelrhodopsin-assisted circuit mapping (CRACM) of long-range inputs to S1 GABAergic subtypes in mice.",
  "effect_size": "Motor → VIP synaptic strengths exceeded those onto PV/SST; somatosensory → PV cells dominated.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "single_study",
  "_source_cluster_index": 38,
  "claim_source_sentence": "Inputs from whisker-related primary motor cortex are biased to vasoactive intestinal peptide (VIP)-positive GABAergic neurons and potentially result in VIP neuron-mediated disinhibition.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1."
}

[
  "paper:paper-003795d72de8"
]

[
  {
    "ref": "paper:paper-003795d72de8"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}