Mouse auditory-cortex L5 callosal parvalbumin-expressing (CC-Parv) GABAergic ne…

Mouse auditory-cortex L5 callosal parvalbumin-expressing (CC-Parv) GABAergic neurons differ from neighbouring local L5 Parv neurons: CC-Parv have larger dendritic fields with longer/farther-branching dendrites, delayed action-potential onset at threshold currents, lower firing rates and lower instantaneous frequencies, and altered Kv1.1 expression — establishing CC-Parv as a distinct functional subtype within the broader Parv class with intrinsic properties suited to interhemispheric inhibitory gating.

{
  "n": 0,
  "doi": "10.3389/fncel.2018.00053",
  "claim": "Mouse auditory-cortex L5 callosal parvalbumin-expressing (CC-Parv) GABAergic neurons differ from neighbouring local L5 Parv neurons: CC-Parv have larger dendritic fields with longer/farther-branching dendrites, delayed action-potential onset at threshold currents, lower firing rates and lower instantaneous frequencies, and altered Kv1.1 expression — establishing CC-Parv as a distinct functional subtype within the broader Parv class with intrinsic properties suited to interhemispheric inhibitory gating.",
  "cite_key": "Zurita2018",
  "evidence": "Viral retrograde tracing, biocytin morphology reconstruction and whole-cell patch-clamp electrophysiology of L5 CC-Parv vs L5 Parv neurons in mouse auditory cortex slices.",
  "effect_size": "qualitative — CC-Parv has distinct morpho-electrophysiology from local Parv",
  "text_access": "fulltext",
  "study_system": "mouse auditory cortex L5 callosal Parv (CC-Parv) and local Parv interneurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "layer 5 CC-Parv neurons had larger dendritic fields characterized by longer dendrites that branched farther from the soma, whereas layer 5 Parv neurons had smaller dendritic fields characterized by shorter dendrites that branched nearer to the soma. The layer 5 CC-Parv neurons are characterized by delayed action potential (AP) responses to threshold currents, lower firing rates, and lower instantaneous frequencies compared to the layer 5 Parv neurons",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1093/cercor/bhx025"
  ],
  "effect_size_source_sentence": "larger dendritic fields characterized by longer dendrites that branched farther from the soma"
}

[
  "paper:paper-65c3717caa0c"
]

layer 5 CC-Parv neurons had larger dendritic fields characterized by longer dendrites that branched farther from the soma, whereas layer 5 Parv neurons had smaller dendritic fields characterized by shorter dendrites that branched nearer to the soma. The layer 5 CC-Parv neurons are characterized by delayed action potential (AP) responses to threshold currents, lower firing rates, and lower instantaneous frequencies c...

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