Single-cell electroporation followed by two-photon serial-section tomography of…

Single-cell electroporation followed by two-photon serial-section tomography of individual mouse barrel-cortex L2/3 excitatory neurons reveals that each neuron has an extensive local intra-barrel axon plus brain-wide axonal arborizations innervating multiple long-range targets (S2; primary somatosensory cortex of upper limb, trunk, lower limb; M1; M2; visual and auditory cortices; dorsolateral striatum; fiber bundles), demonstrating substantial single-cell heterogeneity of long-range targeting within the L2/3 IT class.

{
  "n": 0,
  "doi": "10.3389/fnana.2021.791015",
  "claim": "Single-cell electroporation followed by two-photon serial-section tomography of individual mouse barrel-cortex L2/3 excitatory neurons reveals that each neuron has an extensive local intra-barrel axon plus brain-wide axonal arborizations innervating multiple long-range targets (S2; primary somatosensory cortex of upper limb, trunk, lower limb; M1; M2; visual and auditory cortices; dorsolateral striatum; fiber bundles), demonstrating substantial single-cell heterogeneity of long-range targeting within the L2/3 IT class.",
  "cite_key": "Liu2022b",
  "evidence": "Single-cell electroporation labeling, two-photon serial-section tomography of single barrel-cortex L2/3 pyramidal neurons and registration to a digital brain atlas in mouse.",
  "effect_size": "qualitative — diverse single-cell long-range target spectra within L2/3 IT class",
  "text_access": "fulltext",
  "study_system": "mouse primary whisker somatosensory cortex (barrel cortex) L2/3 excitatory neurons",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Each neuron had an extensive local axon within the barrel cortex. In addition, individual neurons innervated subsets of secondary somatosensory cortex; primary somatosensory cortex for upper limb, trunk, and lower limb; primary and secondary motor cortex; visual and auditory cortical regions; dorsolateral striatum; and various fiber bundles",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.3389/fnana.2018.00033"
  ],
  "effect_size_source_sentence": "individual neurons innervated subsets of secondary somatosensory cortex... primary and secondary motor cortex; visual and auditory cortical regions"
}

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Each neuron had an extensive local axon within the barrel cortex. In addition, individual neurons innervated subsets of secondary somatosensory cortex; primary somatosensory cortex for upper limb, trunk, and lower limb; primary and secondary motor cortex; visual and auditory cortical regions; dorsolateral striatum; and various fiber bundles

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