Mice carrying the human α5-nAChR rs16969968 risk SNP or α5 knockout show reduce…

{
  "n": null,
  "doi": "10.1038/nm.4274",
  "year": "2017",
  "claim": "Mice carrying the human α5-nAChR rs16969968 risk SNP or α5 knockout show reduced VIP-interneuron activity and disinhibition of SST → pyramidal in PFC, producing hypofrontality and behavioural deficits that chronic nicotine reverses.",
  "title": "Nicotine reverses hypofrontality in animal models of addiction and schizophrenia",
  "journal": "",
  "species": "mouse",
  "cite_key": "Koukouli2017",
  "evidence": "Two-photon imaging in awake α5-SNP/α5-KO mice + behavioral tests + chronic nicotine.",
  "effect_size": "Chronic nicotine restored VIP activity and reversed PFC hypofrontality.",
  "text_access": "fulltext",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "single_study",
  "_source_cluster_index": 17,
  "claim_source_sentence": "In α5-SNP-expressing and α5-knockout mice, lower activity of vasoactive intestinal polypeptide (VIP) interneurons resulted in an increased somatostatin (SOM) interneuron inhibitory drive over layer II/III pyramidal neurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Chronic nicotine administration reversed this hypofrontality, suggesting that administration of nicotine may represent a therapeutic strategy for the treatment of schizophrenia."
}

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]

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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