LSPS connectivity-matrix mapping shows that mouse vibrissal M1, vS1 and S2 each…

LSPS connectivity-matrix mapping shows that mouse vibrissal M1, vS1 and S2 each have distinct laminar excitatory architectures: vM1 is dominated by an L2/3→upper-L5 descending pathway, while vS1 and S2 each carry strong L4→L3 ascending and L2/3→L5 descending pathways, with S2 additionally exhibiting L6↔L5B interactions.

{
  "n": 0,
  "doi": "10.1371/journal.pbio.1000572",
  "claim": "LSPS connectivity-matrix mapping shows that mouse vibrissal M1, vS1 and S2 each have distinct laminar excitatory architectures: vM1 is dominated by an L2/3→upper-L5 descending pathway, while vS1 and S2 each carry strong L4→L3 ascending and L2/3→L5 descending pathways, with S2 additionally exhibiting L6↔L5B interactions.",
  "cite_key": "Hooks2011",
  "evidence": "Glutamate-uncaging LSPS input maps across cortical depth in mouse vM1, vS1 and S2 coronal slices, summarized as area-specific neuron→neuron and layer→layer connectivity matrices.",
  "effect_size": "qualitative — area-specific laminar excitatory architecture across three whisker-related cortices",
  "text_access": "fulltext",
  "study_system": "mouse vibrissal motor (vM1), primary somatosensory (vS1) and secondary somatosensory (S2) cortices",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "vM1 contains a strong pathway from L2/3 to upper L5; that vS1 and S2 contain two strong pathways, corresponding to L4→L3 and L2/3→L5; and that S2 contains these plus pathways between L6 and L5B",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/nn.2538"
  ],
  "effect_size_source_sentence": "our main findings were that vM1 contains a strong pathway from L2/3 to upper L5; that vS1 and S2 contain two strong pathways"
}

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