These results indicate that medication use is associated with substantial diffe…

These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.

{
  "n": null,
  "doi": "10.1038/s41398-020-01013-y",
  "claim": "These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.",
  "cite_key": "Bruin2020",
  "evidence": " (, 2020); Bruin WB, Taylor L, Thomas RM, Shock JP, Zhutovsky P, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Assogna F, Benedetti F, Beucke JC, Boedhoe PSW, Bollettini I, Bose A, Brem S, Brennan BP, Buite",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.",
  "replication_evidence_dois": [
    "10.18553/jmcp.2026.32.4.507",
    "10.31234/osf.io/fnt5z_v1"
  ],
  "effect_size_source_sentence": "LOSO-CV led to lower classification performance; 0.51 (95% CI = 0.4–0.62; p corrected = 1) to 0.54 (95% CI = 0.42–0.65; p corrected = 1) AUC with relatively high variance across folds (SD = 0.07–0.11) and no classifiers surviving multiple comparison corrections."
}

[
  "paper:paper-396f794ce8df"
]

These results indicate that medication use is associated with substantial differences in brain anatomy that are widely distributed, and indicate that clinical heterogeneity contributes to the poor performance of structural MRI as a disease marker.

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