AAV-mediated striatal delivery of BDNF or GDNF protects medium spiny and parval…

Details

scope: Quinolinic-acid striatal lesion rat model of HD
claim_text: AAV-mediated striatal delivery of BDNF or GDNF protects medium spiny and parvalbumin/NOS interneurons from quinolinic-acid excitotoxic injury in a rat HD model.
section_id: section_14
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-14
source_kind: review_finding
source_path: evidence/section_14_evidence_package.json
source_span: Both AAV-BDNF and AAV-GDNF significantly reduced the loss of both NeuN- and calbindin-immunopositive striatal neurons 2 weeks after lesion compared to controls.
study_system: Quinolinic-acid striatal lesion rat model of HD
section_title: Loop Dysfunction in Neurological and Psychiatric Disease
evidence_summary: Adult Wistar rats with intrastriatal AAV-BDNF, AAV-GDNF, AAV-GFP, or PBS, then quinolinic acid lesion; NeuN and calbindin counts.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-14
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.ymthe.2004.02.016",
  "claim": "AAV-mediated striatal delivery of BDNF or GDNF protects medium spiny and parvalbumin/NOS interneurons from quinolinic-acid excitotoxic injury in a rat HD model.",
  "cite_key": "Kells2004",
  "evidence": "Adult Wistar rats with intrastriatal AAV-BDNF, AAV-GDNF, AAV-GFP, or PBS, then quinolinic acid lesion; NeuN and calbindin counts.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Quinolinic-acid striatal lesion rat model of HD",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Both AAV-BDNF and AAV-GDNF significantly reduced the loss of both NeuN- and calbindin-immunopositive striatal neurons 2 weeks after lesion compared to controls.",
  "replication_evidence_dois": [
    "10.1042/bst20253079",
    "10.1002/smll.202510539"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-a4e79b69859a"
]

evidence_refs

[
  {
    "ref": "paper:paper-a4e79b69859a"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

AAV-mediated striatal delivery of BDNF or GDNF protects medium spiny and parval…

Details

Replication

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