In awake Parkinson patients, mean GPe firing rate is ~42 Hz and mean GPi firing…

Details

scope: Human Parkinson's disease patients undergoing pallidotomy (47 patients; 152 GPe + 203 GPi single units)
claim_text: In awake Parkinson patients, mean GPe firing rate is ~42 Hz and mean GPi firing rate is ~81 Hz, distinguishable by burst, pause, and pause-ratio indices.
section_id: section_14
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
effect_size: GPi 81 Hz vs GPe 42 Hz
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-14
source_kind: review_finding
source_path: evidence/section_14_evidence_package.json
source_span: GPe discharges had a mean firing rate = 42 Hz, BI = 0.81, PI = 0.21, and PR = 1.41. GPi had a mean firing rate = 81, BI = 1.61, PI = 0.04, and PR = 0.21.
study_system: Human Parkinson's disease patients undergoing pallidotomy (47 patients; 152 GPe + 203 GPi single units)
section_title: Loop Dysfunction in Neurological and Psychiatric Disease
evidence_summary: Single-unit recordings of 152 GPe and 203 GPi cells during pallidotomy; computer-based on-line firing-rate, ISI, and burst/pause analysis.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-14
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 47,
  "doi": "10.1016/s0090-3019(99)00030-0",
  "claim": "In awake Parkinson patients, mean GPe firing rate is ~42 Hz and mean GPi firing rate is ~81 Hz, distinguishable by burst, pause, and pause-ratio indices.",
  "cite_key": "Favre1999",
  "evidence": "Single-unit recordings of 152 GPe and 203 GPi cells during pallidotomy; computer-based on-line firing-rate, ISI, and burst/pause analysis.",
  "effect_size": "GPi 81 Hz vs GPe 42 Hz",
  "text_access": "abstract_only",
  "study_system": "Human Parkinson's disease patients undergoing pallidotomy (47 patients; 152 GPe + 203 GPi single units)",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "GPe discharges had a mean firing rate = 42 Hz, BI = 0.81, PI = 0.21, and PR = 1.41. GPi had a mean firing rate = 81, BI = 1.61, PI = 0.04, and PR = 0.21.",
  "replication_evidence_dois": [
    "10.3233/jpd-130204",
    "10.1016/0166-2236(90)90110-v"
  ],
  "effect_size_source_sentence": "GPe discharges had a mean firing rate = 42 Hz, BI = 0.81, PI = 0.21, and PR = 1.41. GPi had a mean firing rate = 81, BI = 1.61, PI = 0.04, and PR = 0.21."
}

source_refs

[
  "paper:paper-49ae95428ec6"
]

evidence_refs

[
  {
    "ref": "paper:paper-49ae95428ec6"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops"
}

In awake Parkinson patients, mean GPe firing rate is ~42 Hz and mean GPi firing…

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