Pharmacologically-imposed rate-model conditions in SNr neurons (excess NMDA dri…

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scope: Rat substantia nigra pars reticulata neurons in acute brain slices
claim_text: Pharmacologically-imposed rate-model conditions in SNr neurons (excess NMDA drive plus reduced GABA-A inhibition) generate bursting consistent with the oscillatory model, reconciling the rate vs. oscillatory accounts.
section_id: section_14
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
review_repo: ComputationalReviewLoops
section_ref: wiki_page:computationalreviewloops-14
source_kind: review_finding
source_path: evidence/section_14_evidence_package.json
source_span: Therefore synaptic changes forecasted by the rate model induce the electrical behavior predicted by the oscillatory model.
study_system: Rat substantia nigra pars reticulata neurons in acute brain slices
section_title: Loop Dysfunction in Neurological and Psychiatric Disease
evidence_summary: In vitro slice recordings of SNr projection neurons; bath application of NMDA + GABA-A blockers; CaV3.2 T-type channels identified as indispensable for bursting initiation.
review_bundle_ref: analysis_bundle:ab-d49e54403ef9
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-d49e54403ef9
source_artifact_ref: wiki_page:computationalreviewloops-14
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_14_evidence_package.json
commit_sha: 0632aae8abc141909207fe91f6349b9e36489c3b
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewLoops

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1152/jn.00620.2007",
  "claim": "Pharmacologically-imposed rate-model conditions in SNr neurons (excess NMDA drive plus reduced GABA-A inhibition) generate bursting consistent with the oscillatory model, reconciling the rate vs. oscillatory accounts.",
  "cite_key": "Ibanez2007",
  "evidence": "In vitro slice recordings of SNr projection neurons; bath application of NMDA + GABA-A blockers; CaV3.2 T-type channels identified as indispensable for bursting initiation.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Rat substantia nigra pars reticulata neurons in acute brain slices",
  "source_cluster_id": "cluster_13",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Therefore synaptic changes forecasted by the rate model induce the electrical behavior predicted by the oscillatory model.",
  "replication_evidence_dois": [
    "10.4081/ijfs.2025.13828",
    "10.1002/psp4.70112"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-8e35832dc5f6"
]

evidence_refs

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source_policy

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Pharmacologically-imposed rate-model conditions in SNr neurons (excess NMDA dri…

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