- claim_text
In mouse dorsomedial prefrontal cortex during a delayed Go/No-Go task, optogenetic activation of SST or PV interneurons (but NOT VIP) impairs delay-period maintenance and task performance — establishing differential interneuron-type contributions to working memory and the role of disinhibition.
- raw_fields
{
"n": null,
"doi": "10.1038/nn.4554",
"claim": "In mouse dorsomedial prefrontal cortex during a delayed Go/No-Go task, optogenetic activation of SST or PV interneurons (but NOT VIP) impairs delay-period maintenance and task performance — establishing differential interneuron-type contributions to working memory and the role of disinhibition.",
"title": null,
"cite_key": "Kamigaki2017",
"evidence": "Optogenetic activation of PV/SST/VIP cells + 2P imaging in mouse dmPFC during delayed task.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse dmPFC; in vivo opto + 2P",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "replicates",
"_source_cluster_index": 75,
"claim_source_sentence": "In contrast, activating vasoactive intestinal polypeptide-positive interneurons did not alter delay activity or task performance — distinguishing VIP from SST/PV in working-memory maintenance.",
"replication_evidence_dois": [
"10.1016/j.neuron.2015.06.021"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-6552e7a00e2e"
]
- evidence_refs
[
{
"ref": "paper:paper-6552e7a00e2e"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}