- claim_text
In mouse V1 during a cross-modal attention task, bi-directional optogenetic manipulation of VIP interneurons does NOT replicate or interact with attentional modulation of pyramidal cells; VIP-SOM disinhibition is therefore orthogonal to attention rather than mediating it.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2023.11.006",
"claim": "In mouse V1 during a cross-modal attention task, bi-directional optogenetic manipulation of VIP interneurons does NOT replicate or interact with attentional modulation of pyramidal cells; VIP-SOM disinhibition is therefore orthogonal to attention rather than mediating it.",
"title": null,
"cite_key": "Myersjoseph2024",
"evidence": "All-optical bidirectional VIP optogenetic perturbation + simultaneous 2P imaging of VIP/SOM/PV/Pyr in mouse V1 during cross-modal attention.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse V1; all-optical attention task",
"_source_cluster": "cluster_05_synaptic_connectivity",
"replication_status": "conflicts",
"_source_cluster_index": 42,
"claim_source_sentence": "we found that although activity of VIP cells was strongly modulated by attention, optogenetic manipulation of VIP cells did not replicate the effect of attention on pyramidal cells.",
"replication_evidence_dois": [
"10.1126/science.1254126"
],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-bcc613ccccd9"
]
- evidence_refs
[
{
"ref": "paper:paper-bcc613ccccd9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}