In adult mouse barrel cortex, whisker-evoked PSPs paired with action potentials…

In adult mouse barrel cortex, whisker-evoked PSPs paired with action potentials produce spike-timing-dependent LTP only for receptive-field-center whiskers; partial whisker trimming rapidly opens STD-LTP from spared surround whiskers, associated with deprivation-induced reduction in surround-evoked inhibition.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2012.05.020",
  "claim": "In adult mouse barrel cortex, whisker-evoked PSPs paired with action potentials produce spike-timing-dependent LTP only for receptive-field-center whiskers; partial whisker trimming rapidly opens STD-LTP from spared surround whiskers, associated with deprivation-induced reduction in surround-evoked inhibition.",
  "cite_key": "Gambino2012",
  "evidence": "STD-LTP at L2/3 pyramidal synapses was center-only in normal animals; after whisker trimming, spared surround whiskers could drive STD-LTP, accompanied by a strong drop in surround-evoked inhibitory conductance and partial occlusion by picrotoxin LTP facilitation.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse barrel cortex L2/3 pyramidal neurons, in vivo / ex vivo (whisker stimulation + paired protocol)",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "This spike-timing-dependent long-term potentiation (STD-LTP) was only effective for PSPs evoked by deflections of a whisker in the neuron's receptive field center, and not its surround.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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STD-LTP at L2/3 pyramidal synapses was center-only in normal animals; after whisker trimming, spared surround whiskers could drive STD-LTP, accompanied by a strong drop in surround-evoked inhibitory conductance and partial occlusion by picrotoxin LTP facilitation.