The original Neuropixels probe integrates 384 simultaneously recorded channels…

The original Neuropixels probe integrates 384 simultaneously recorded channels addressing 960 sites on a single 10-mm shank, and two such probes recorded >700 well-isolated single neurons across five brain structures simultaneously in awake mouse — anchoring the present-day baseline for multi-area extracellular recording in mouse cortex.

{
  "n": 700,
  "doi": "10.1038/nature24636",
  "claim": "The original Neuropixels probe integrates 384 simultaneously recorded channels addressing 960 sites on a single 10-mm shank, and two such probes recorded >700 well-isolated single neurons across five brain structures simultaneously in awake mouse — anchoring the present-day baseline for multi-area extracellular recording in mouse cortex.",
  "cite_key": "Jun2017",
  "evidence": "Original Neuropixels probe architecture; two-probe demonstration recorded >700 single units across 5 awake-mouse brain structures simultaneously.",
  "effect_size": ">700 well-isolated single neurons recorded simultaneously from 5 brain structures with two probes",
  "text_access": "abstract_only",
  "study_system": "Awake mouse, multi-structure extracellular recording",
  "argument_role": "supporting",
  "replication_status": "single-platform",
  "claim_source_sentence": "Each probe has 384 recording channels that can programmably address 960 complementary metal-oxide-semiconductor (CMOS) processing-compatible low-impedance TiN sites that tile a single 10-mm long, 70 × 20-μm cross-section shank.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Using two probes, more than 700 well-isolated single neurons were recorded simultaneously from five brain structures in an awake mouse."
}

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]

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  {
    "ref": "paper:6f999156-d57b-49f0-a236-2c549c1190d6"
  }
]

15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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