Neuropixels 2.0 probes enable chronic recording from the same mouse visual-cort…

{
  "n": 0,
  "doi": "10.1101/2020.10.27.358291",
  "claim": "Neuropixels 2.0 probes enable chronic recording from the same mouse visual-cortex neurons for over two months by combining >5,000 sites, ~1 g weight including headstage, and post-hoc motion-stabilization algorithms.",
  "cite_key": "Steinmetz2020",
  "evidence": "Quantifies the present-day chronic-recording window achievable with the current generation of dense extracellular probes — a hard constraint cluster_14 must report.",
  "effect_size": ">5,000 sites per probe; two probes + headstage ~1 g; 768 sites recorded simultaneously; >10,000-site recordings during free behavior",
  "text_access": "abstract_only",
  "study_system": "Mouse and rat; Neuropixels 2.0 chronic recordings, six labs (two species)",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "Improved site density and arrangement combined with new data processing methods enable automatic post-hoc stabilization of data despite brain movements during behavior and across days, allowing recording from the same neurons in the mouse visual cortex for over 2 months.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1101/2024.04.25.591118"
  ],
  "effect_size_source_sentence": "The new probe has over 5,000 sites and is miniaturized such that two probes plus a headstage, recording 768 sites at once, weigh just over 1 g, suitable for implanting chronically in small mammals."
}

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Improved site density and arrangement combined with new data processing methods enable automatic post-hoc stabilization of data despite brain movements during behavior and across days, allowing recording from the same neurons in the mouse visual cortex for over 2 months.

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15. Methodological limits and emerging tools — what current mouse-cortex tools cannot yet measure about E→E recurrence (subthreshold network activity, fast plasticity in vivo, millimetre-scale dynamic connectomes), and what is on the near horizon

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